Preheat the oven to 375°F.
In a large mixing bowl, combine the uncooked penne pasta, marinara sauce, low-sodium chicken broth, sea salt, black pepper, and diced chicken breasts. Stir until all ingredients are well mixed and the pasta is evenly coated with sauce.
Transfer the mixture into a greased casserole dish, spreading it out evenly with a spatula.
Cover the casserole dish with aluminum foil and place it in the preheated oven. Bake for 30 minutes, allowing the flavors to meld and the pasta to cook through.
In a small bowl, combine the grated Parmesan cheese, Panko breadcrumbs, melted unsalted butter, and Italian seasoning. This mixture will add a crispy and savory topping.
After 30 minutes, carefully remove the casserole from the oven. Take off the aluminum foil.
Sprinkle the shredded mozzarella cheese evenly over the top of the casserole to create a melty layer.
Evenly distribute the Parmesan streusel over the mozzarella layer.
Return the uncovered casserole dish to the oven and bake for an additional 15 minutes, or until the cheese is melted and bubbly and the topping is golden brown.
Once done, remove the casserole from the oven and allow it to cool for 5 to 10 minutes. Sprinkle with fresh chopped herbs such as basil or parsley for a pop of color and freshness.
Serve hot, spooning generous portions onto plates.