In a shallow dish combine the crumbs, grated parmesan, garlic powder, onion powder, salt and pepper; mix until thoroughly incorporated.
Lightly spray the fillets with cooking spray, then dredge them in the cheese and crumb mixture, pressing the mixture onto the fillets with your fingers to ensure it adheres well.
Arrange 2 tilapia filets in a single layer inside the air fryer basket; do not crowd the basket because it will steam the fish rather than fry.
Cook for 5 to 6 minutes, or until golden brown and internal temperature registers at 145˚F.
Remove fish from air fryer and continue to cook the rest.