Cheesy Chicken Spaghetti

5 from 7 votes

This Cheesy Chicken Spaghetti casserole features a creamy sauce packed with juicy canned tomatoes, plenty of cheese, and tender chunks of chicken.

Prep Time20

Cook Time35

Resting Time5

Total Time1

Course: Dinner

Cuisine: American

Keyword: cheesy chicken spaghetti, cheesy chicken spaghetti recipe, chicken spaghetti

Servings: servings

Calories: 559kcal

Cook the spaghetti according to the package directions until al dente, about 7 to 8 minutes. Drain and set aside.
Preheat the oven to 350°F.
In a mixing bowl, combine the cubed chicken with Italian seasoning, garlic powder, sea salt, and black pepper.
In a large skillet, Dutch oven, or Braiser, heat the olive oil over medium-high heat. Add the seasoned chicken and cook it until browned and cooked through, about 6 minutes. Remove from the skillet and set aside.
In the same skillet, melt the unsalted butter over medium heat.
Add in the cream of chicken soup, softened cream cheese, diced tomatoes, chicken broth, and shredded Mexican cheese blend. Mix everything well until the cheese has melted and the mixture is smooth and creamy.
Stir in the cooked chicken and prepared spaghetti until evenly combined.
Sprinkle shredded mozzarella cheese over the top of the spaghetti and chicken mixture.
Cover the skillet or Dutch oven with a lid or cover it well with aluminum foil; bake it in the oven for about 30 minutes. For a browned top, remove the lid, turn the oven to broil, and cook it until the cheese is lightly browned in spots, about 3 to 5 minutes.
Once done, remove it from the oven and let it rest for 5 to 8 minutes. Garnish with fresh basil and serve.